ea0034p250 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014
Richards James E
, Cork Simon C
, Holt Marie
, Reimann Frank
, Gribble Fiona M
, Trapp Stefan
Glucagon like peptide-1 (GLP-1) is derived from selective cleavage of the preproglucagon (PPG) molecule synthesised in intestinal L-cells. The physiological action of GLP-1 is most commonly recognised as a peripherally released incretin, but a subset of neurons in the lower brainstem, the PPG neurons, also express GLP-1. The majority of PPG neuronal cell bodies are located in the nucleus of the solitary tract and their axons project to numerous sites throughout the CNS. Many o...